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Updated: Jun 21, 2026

Examination of Thymic Positive and Negative Selection by Flow Cytometry
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Published on: October 8, 2012

bcl-2 抑制了多种形式的亡,但并未抑制发细胞中的负选择

C L Sentman1, J R Shutter, D Hockenbery

  • 1Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.

Cell
|November 29, 1991
PubMed
概括

在发育中的T细胞中,bcl-2蛋白质可以防止被编程的细胞死亡 (细胞亡). 将bcl-2重定向到不成熟的胸细胞保护它们免受亡,但并没有完全阻止T细胞选择,揭示了不同的死亡途径.

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