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Updated: May 5, 2026

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
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由TGF-β诱导的Foxp3通过对抗RORgammat功能来抑制T(H) 17细胞分化

Liang Zhou1, Jared E Lopes, Mark M W Chong

  • 1The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA.

Nature
|March 28, 2008
PubMed
概括

转化生长因子-β (TGF-β) 度决定了T助手17 (T(H) 17和调控性T (T(reg)) 细胞的分化. 低TGF-β促进T(H) 17细胞,而高TGF-β则通过平衡RORgammat和Foxp3转录因子,有利于T(reg) 细胞.

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