心脏自主功能障碍:来自微粒空气污染的影响,以及通过饮食中的甲基营养素和代谢多态性保护
Andrea Baccarelli1, Patricia A Cassano, Augusto Litonjua
1Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02215, USA. abaccare@hsph.harvard.edu
Circulation
|April 2, 2008
概括
空气中的颗粒物污染 (PM2.5) 对心率变化产生负面影响,特别是在具有特定MTHFR基因变异的个体中. 然而,通过饮食摄入足够的甲基营养素,如B6,B12和氨酸,可以防止这些有害影响.
科学领域:
- 环境健康 环境健康
- 心血管健康 心血管健康
- 营养科学 营养科学
背景情况:
- 空气中的颗粒物污染 (PM2.5) 是心血管疾病的已知危险因素.
- 了解PM2.5对心血管健康影响的机制和修改因素至关重要.
研究的目的:
- 研究饮食中的甲基营养素和特定基因多态性如何影响PM2.5暴露和心率变化之间的关系.
- 在空气污染和心血管健康的背景下,确定保护性和易感性因素.
主要方法:
- 对549名老年男性的心率变化和饮食数据的分析.
- 评估PM2.5暴露对心率变化的影响,与MTHFR和cSHMT基因多态性相关.
- 评估饮食中的叶酸,维生素B6,B12和甲因的修饰作用.
主要成果:
- 在MTHFR[CT/TT]基因型的携带者和在PM2.5暴露后的[CC]cSHMT携带者中观察到心率变化减少.
- 在饮食中摄入维生素B6,B12和甲因的较高人群中,PM2.5对心率变化的负面影响减少了.
- 在具有[CC] MTHFR或[CT/TT] cSHMT基因型的受试者中,没有发现有意义的PM2.5心率变化相关性.
结论:
- 在MTHFR和cSHMT基因的遗传变异,以及饮食中摄入的甲基营养素,在调节PM2.5.5的心血管影响方面发挥着重要作用.
- 氨酸循环涉及到对心率波动的独立影响和改变空气污染的影响.
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