一种与尼古丁依赖,肺癌和外围动脉疾病相关的变体
Thorgeir E Thorgeirsson1, Frank Geller1, Patrick Sulem1
1deCODE Genetics, Reykjavik Iceland.
Nature
|April 4, 2008
概括
一种常见的遗传变异影响吸烟量,尼古丁依赖以及肺癌和外围动脉疾病的风险. 这一发现突显了吸烟相关疾病中的基因环境相互作用.
科学领域:
- 遗传学 遗传学是一种遗传学.
- 公共卫生 公共卫生
- 分子生物学分子生物学
背景情况:
- 吸烟是全球可预防死亡的主要原因,每年导致数百万个过早死亡.
- 众所周知,遗传因素会影响吸烟行为和尼古丁依赖 (ND),因此需要识别易感基因.
- 了解基因序列变异对吸烟相关疾病的影响对于公共卫生倡议至关重要.
研究的目的:
- 为了确定与吸烟量,尼古丁依赖和吸烟相关疾病风险相关的常见遗传变异.
- 调查尼古丁乙胆受体基因群中的特定变异在染色体15q24上的作用.
- 探索基因与环境的相互作用,特别是尼古丁成与疾病病理学的联系.
主要方法:
- 全基因组关联研究 (GWAS) 方法用于识别遗传变异.
- 在尼古丁乙胆受体基因集群 (15q24) 中分析一种常见变异.
- 协会研究检查吸烟量,尼古丁依赖 (ND),肺癌 (LC) 和外围动脉疾病 (PAD) 在欧洲血统的人群中.
主要成果:
- 鉴定出15q24染色体的一个常见变异对每天吸烟的香烟数量有显著影响.
- 同一个变体显示出与尼古丁依赖 (ND) 的高度显著关联.
- 发现这种变种增加了肺癌 (LC) 和外围动脉疾病 (PAD) 的风险.
结论:
- 鉴定的基因变异在吸烟量,尼古丁依赖和易患主要吸烟相关疾病方面发挥着作用.
- 这一发现说明了基因与环境的相互作用,强调了尼古丁成在疾病发展中的重要性.
- 这项研究为吸烟行为和相关健康结果的遗传基础提供了宝贵的见解.
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