纳米粒子MALDI-TOF质谱没有碎片化:Au25(SCH2CH2Ph) 18和混合单层Au25(SCH2CH2Ph) 18-x) L) x)
Amala Dass1, Anthony Stevenson, George R Dubay
1Kenan Laboratories of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599-3290, USA.
Journal of the American Chemical Society
|April 9, 2008
概括
这项研究展示了一种使用MALDI-TOF质谱仪观察完整黄金纳米粒子的新方法. 这种技术防止了碎片化,允许精确分析纳米粒子组成.
科学领域:
- *纳米粒子的表征
- * 质谱测量 质谱测量
- * 表面的化学成分
背景情况:
- *传统的MALDI-TOF质谱法经常导致金纳米粒子及其连接体的碎片化.
- *分析纳米颗粒上混合单层的组成是具有挑战性的,因为碎片化.
研究的目的:
- * 开发一种非碎片化的MALDI-TOF质谱法,用于分析金纳米颗粒.
- * 为了能够精确地确定金纳米颗粒上的混合单层组成.
- * 确定合成特定混合单层化合物的反应条件.
主要方法:
- * 在 MALDI-TOF 质谱学中使用值激光脉冲强度.
- *采用变-2-[3-(4-三甲基-丁) 2-甲基-2-乙烯基]malononitrile (DCTB) 作为一个矩阵.
- * 在 7391 Da 中分析 Au25 ((SCH2CH2Ph) 18) 的完整分子离子,以负和正两种模式.
主要成果:
- * 在7391Da时观察到完整的Au25(SCH2CH2Ph) 18分子离子,具有同位素分辨率.
- *该方法成功避免了纳米粒子及其酸连体的碎片化.
- * 可以精确地确定混合单层分布.
- *确定了特定连接物组成的反应条件.
结论:
- *开发的MALDI-TOF方法提供了一种非破坏性的方法来分析黄金纳米粒子.
- * 这种技术对于理解和控制纳米粒子表面化学是至关重要的.
- * 它有助于合成具有所需混合单层功能的纳米粒子.
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