上肠的脂质触发了肠-大脑-肝轴,以调节葡萄糖的生产
Penny Y T Wang1, Liora Caspi, Carol K L Lam
1Toronto General Hospital Research Institute, University Health Network, Toronto M5G 1L7, Canada.
Nature
|April 11, 2008
概括
上部肠道脂质激活一个神经通路,涉及肠道,大脑和肝脏,以抑制葡萄糖的生产. 这种新发现的肠-脑-肝轴对于调节葡萄糖平衡至关重要.
科学领域:
- 代谢生理学 代谢生理学
- 神经内分泌学神经内分泌学
- 胃肠道生理学 胃肠道生理学
背景情况:
- 能量和葡萄糖平衡取决于食物摄入量和肝脏的葡萄糖生产.
- 上肠在营养吸收中起着关键作用,并通过肠-大脑轴影响食物摄入.
- 一个脑肝轴已被提出,以调节基于血脂水平的葡萄糖生产.
研究的目的:
- 为了研究上肠脂质激活肠-大脑-肝脏神经轴调节葡萄糖平衡的假设.
- 阐明参与上肠脂质感应的神经通路及其对葡萄糖生产的影响.
主要方法:
- 直接将脂质注入动物的上肠.
- 药理上抑制乙-CoA合成和神经通路 (四甲,MK-801).
- 外科干预包括腹膜下阴道切除术,肠道阴道脱分和肝脏阴道切除术.
主要成果:
- 上肠道脂质增加了长链脂肪酸-CoA (LCFA-CoA) 水平,并抑制了肝脏的葡萄糖生产.
- 抑制LCFA-CoA合成或神经阻塞取消了脂质诱导的抑制葡萄糖的产生.
- 吸血术和MK-801的中央管理破坏了肠-大脑-肝脏信号传输,阻止了葡萄糖生产的抑制.
结论:
- 上部肠道脂质激活连接肠道,大脑和肝脏的神经轴,以抑制葡萄糖的产生.
- 这条由LCFA-CoA调解并涉及神经信号传递的途径代表了调节葡萄糖平衡的新机制.
- 这些发现揭示了上肠在感知脂质以控制肝脏葡萄糖输出方面之前不被重视的作用.
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