相关实验视频
洛巴化物E的总合成,一种强大的抗瘤循环三烯沙宁
Chunsheng Zhu1, Pingping Tang, Biao Yu
1State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
Journal of the American Chemical Society
|April 15, 2008
概括
研究人员首次合成了Lobatoside E,这是一个具有强烈抗瘤活性的复杂循环三二桑. 这种新型合成通过73步模块化方法实现了1.2%的整体收益率.
科学领域:
- 有机化学 有机化学
- 药用化学 医学化学
- 自然产品的合成自然产品的合成
背景情况:
- 洛巴化物E是一种复杂的循环三三桑素.
- 它表现出强大的抗瘤活性.
- 它的总合成以前没有报道过.
研究的目的:
- 为了首次实现洛巴托E的全合成,E.
- 开发一个高度模块化的复杂氨酸的合成策略.
主要方法:
- 采用了模块化合成方法.
- 合成始于随时可用的起始材料:烯酸,D-葡萄糖,D-银糖,L-阿拉比诺斯和L-拉姆诺斯.
- 合成路线共涉及73个步骤.
主要成果:
- 洛巴化物E的总合成成功完成.
- 合成中最长的线性序列包括31个步骤.
- 目标分子的总产量达到了1.2%.
结论:
- 已经建立了第一个Lobatoside E的完全合成,这是一种强大的抗瘤剂.
- 一个高度模块化的策略使得复杂的循环三二桑的合成成为可能.
- 这种合成途径为进一步的生物评估提供了Lobatoside E的获取.
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