加多酸涂层金纳米颗粒作为X射线计算机断层扫描和磁共振成像的对比剂
Christophe Alric1, Jacqueline Taleb, Géraldine Le Duc
1Laboratoire de Physico-Chimie des Matériaux Luminescents, UMR 5620 CNRS-Université Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France.
Journal of the American Chemical Society
|April 15, 2008
概括
功能化的金纳米粒子通过结合金的X射线对比度和加多的MRI对比度来提供双模式成像. 这些新型纳米粒子在血液中循环,而不会在主要器官中积累.
科学领域:
- 纳米技术 纳米技术
- 生物医学成像技术 生物医学成像技术
- 材料科学 材料科学 材料科学
背景情况:
- 为多种成像模式开发有效的对比剂仍然是一个挑战.
- 黄金纳米粒子 (AuNPs) 为X射线成像提供了独特的特性.
- 加多酸被广泛用于磁共振成像 (MRI) 中的对比剂.
研究的目的:
- 开发和评估功能化黄金纳米粒子作为体内X射线和MRI的双模式对比剂.
- 研究这些新型纳米粒子的成像能力和生物分布.
主要方法:
- 在多层有机外中封装的金纳米颗粒的合成.
- 有机外包含加多合物,通过二硫化键连接在一起.
- 在体内评估X射线和MRI对比度增强和生物分布.
主要成果:
- 功能化的金纳米粒子在X射线和MRI中都表现出有效的对比度增强.
- 金芯提供了强大的X射线吸收,而被困的加多离子增强了MRI信号.
- 颗粒在血管中呈现良好的循环,在肺,或肝脏没有显著的积累.
结论:
- 功能化的金纳米粒子作为多功能双模态对比剂.
- 这些纳米粒子对先进的体内成像应用有前途.
- 观察到的生物分布表明,临床转化具有有利的安全性.
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