抑制 ангиотензин转化酶可以改善风湿性关节炎患者的血管功能
Andreas J Flammer1, Isabella Sudano, Frank Hermann
1Cardiovascular Centre, Cardiology, University Hospital, Rämistrasse 100, 8091 Zurich, Switzerland.
Circulation
|April 23, 2008
概括
拉米普利在风湿性关节炎患者中显著改善了内皮功能,因为它增强了流媒体扩张. 这种血管激素转化酶抑制剂还减少了炎症标志物,这表明了新的心血管事件预防策略.
科学领域:
- 心血管医学 心血管医学
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 类风湿性关节炎 (RA) 患者面临心血管风险升高.
- 动脉样硬化和RA之间的相似性表明它们有共同的治疗目标.
- ангиотензин转化酶 (ACE) 抑制剂在动脉样硬化血管疾病中已经显示出好处.
研究的目的:
- 评估拉米普利尔对RA患者内皮功能的影响.
- 评估拉米普利尔对炎症和RA中氧化应激标志物的作用.
- 为了确定拉米普利是否可以减轻RA中的心血管风险.
主要方法:
- 随机,双盲,交叉研究涉及11名RA患者.
- 拉米普利尔 (2.5-10毫克) 或安慰剂在标准抗炎疗法之上,服用8周.
- 评估内皮功能 (流媒扩张),炎症标志物,氧化应激和疾病活性.
主要成果:
- 拉米普林显著改善了内皮功能 (流介导扩张从2.85%增加到4.00%,P=0.017).
- 随着拉米普利的使用,心压略有降低 (P=0.03).
- 瘤亡因子-α与流媒体扩张 (r=-0.408,P=0.02) 相反相关;CD40水平下降 (P=0.049).
结论:
- 拉米普利尔 (10 mg/天8周) 在RA患者中显著改善了内皮功能.
- 用拉米普利尔抑制ACE可能为预防RA中心血管事件提供了一种新策略.
- 对降低RA心血管风险的ACE抑制剂的进一步研究是有必要的.
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