40岁以后的长QT综合征
Ilan Goldenberg1, Arthur J Moss, James Bradley
1Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA. Ilan.Goldenberg@heart.rochester.edu
Circulation
|April 23, 2008
概括
40岁以上的先天性长QT综合征 (LQTS) 患者仍然面临显著的心脏事件风险. 诸如性别,近期昏迷和LQT3基因型等因素会影响这个老年人群的结果.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 内部医学 内部医学
背景情况:
- 以前对先天性长QT综合征 (LQTS) 的研究主要集中在年轻人身上.
- 在老年人群中,LQTS的临床轨迹仍未得到充分研究.
研究的目的:
- 调查41至75岁的LQTS患者中危及生命的心脏事件的风险.
- 确定影响老年LQTS患者心脏事件风险的因素.
主要方法:
- 分析了来自国际LQTS注册表的2759名受试者,根据修正的QT间隔 (QTc) 分类.
- 评估不同年龄段 (41-60和61-75) 中断心脏骤停或死亡的风险.
- 评估性别差异,临床病史 (综合征) 和遗传突变 (LQT3基因型) 作为风险因素.
主要成果:
- 41-60岁的LQTS患者与未受影响的个体相比,心脏事件的风险明显更高 (HR2.65).
- 在61至75岁的年龄组中,风险降低了 (HR 1.23),但仍然很高.
- 受影响的妇女的事件率 (26%) 比边界 (16%) 和不受影响的 (12%) 妇女高;男性的发生率在各组中相似.
- 最近的昏迷 (HR 9.92) 和LQT3基因型 (HR 4.76) 是不良事件的显著预测因素.
结论:
- 40岁以上的先天性长QT综合征患者仍然面临严重危及生命的心脏事件的风险.
- 老年人中LQTS的表现是由与年龄相关的因素决定的,包括性别,病史和特定的遗传突变.
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