在小鼠的口腔鼻腔器官中编码性别和个人信息
Jie He1, Limei Ma, Sangseong Kim
1Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.
概括
哺乳动物的吐口鼻腔器官神经元对尿液线索做出反应. 个体和菌株信息由组合神经元激活编码,而性别线索则激活特定细胞群.
科学领域:
- 神经科学是一个神经科学.
- 化学感官 化学感官
- 哺乳动物生物学 哺乳动物生物学
背景情况:
- 哺乳动物的口腔鼻腔器官 (VNO) 检测到重要的社会和生殖化学信号.
- 了解VNO如何编码复杂的信息,如性别,菌株和社会地位仍然是一个挑战.
研究的目的:
- 为了研究哺乳动物口鼻器官内的化学信号的神经编码.
- 分析鼻神经元对不同个体尿液的群体反应.
主要方法:
- 转基因小鼠表达指标G-CaMP2的发展.
- 对口鼻神经元对尿液刺激的响应进行人口级别分析.
主要成果:
- 有相当数量的吐口鼻神经元对男性和女性的尿液都有反应.
- 一个小的神经元群体对特定性别的线索表现出了独特的反应.
- 与男性线索相比,女性线索激活了更多的神经元,并表现出复杂的荷尔蒙调节.
- 菌株和个体身份是通过vomeronasal神经元的组合激活模式编码的.
结论:
- 吐口鼻子器官神经元对性别,菌株和个体特异性的化学线索表现出不同的反应.
- 鼻神经元的组合编码对于传递详细的社会和生殖信息至关重要.
相关概念视频
Physiology of Smell and Olfactory Pathway
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
Olfaction
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
Olfactory Receptors: Location and Structure
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...


