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Updated: Jul 5, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
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通过p38 MAPK进行酸化作为GSK3β失活的替代途径

Tina M Thornton1, Gustavo Pedraza-Alva, Bin Deng

  • 1Department of Medicine/Immunobiology Program, University of Vermont, Burlington, VT 05405-0068, USA.

Science (New York, N.Y.)
|May 3, 2008
PubMed
概括

通过C端酸化,p38基激活蛋白激酶 (MAPK) 通过C端酸化使糖原合成酶激酶3β (GSK3β) 失活. 这种途径与Akt介导的抑制不同,促进β-catenin的积累和细胞在大脑和胸细胞中的存活.

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