人类脂肪细胞周转的动力学
Kirsty L Spalding1, Erik Arner, Pål O Westermark
1Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden. kirsty.spalding@ki.se
Nature
|May 6, 2008
概括
脂肪细胞 (脂肪细胞) 的数量在成年时固定,但每年更新约10%. 这种一致的脂肪细胞周转为肥胖症治疗提供了一个新的目标.
科学领域:
- 代谢障碍 代谢障碍 代谢障碍
- 肥胖研究的研究.
- 人类生理学 人类生理学
背景情况:
- 肥胖是一个全球流行病,增加了心血管疾病和2型糖尿病的风险.
- 成人脂肪质量的决定因素尚不清楚,之前被认为是关键的现有脂肪细胞中的脂质储存.
- 肥胖率的上升可能会降低发达国家的预期寿命.
研究的目的:
- 调查脂肪细胞数作为成年脂肪质量的决定因素的作用.
- 了解成年人脂肪细胞的动态和循环率.
- 为了确定肥胖的潜在治疗点.
主要方法:
- 对基因组DNA中14C集成的分析,以测量脂肪细胞周转率.
- 在不同年龄和体重指数的瘦身和肥胖个体中比较脂肪细胞动态.
- 在早期肥胖症中评估脂肪细胞死亡和生成率.
主要成果:
- 脂肪细胞数量是成年人脂肪质量的主要决定因素,在整个成年期保持不变.
- 大约10%的成年脂肪细胞每年都会更新,不论年龄或BMI.
- 脂肪细胞周转率受到严格监管,在早期发病的肥胖症中没有变化.
结论:
- 脂肪细胞数量是在童年/青春期建立的,在成年后是稳定的.
- 一贯的每年脂肪细胞更新表明稳定群体内的动态过程.
- 高脂肪细胞周转率为药理性肥胖干预提供了一个新的治疗点.
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