线粒体单元组:缺血性心血管疾病,其他疾病,死亡率和一般人口的寿命
Marianne Benn1, Marianne Schwartz, Børge G Nordestgaard
1Department of Clinical Biochemistry, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark.
Circulation
|May 7, 2008
概括
线粒体单质组,常见的遗传变异,研究了它们与欧洲人口疾病风险和寿命的关联. 该研究发现,这些单元组与心血管疾病,其他疾病或死亡率之间没有显著联系.
科学领域:
- 遗传学 是一个遗传学.
- 线粒体DNA是线粒体的DNA.
- 人口研究 人口研究
背景情况:
- 罕见的线粒体DNA突变会导致疾病.
- 常见的线粒体单元组与疾病风险和寿命有关.
- 在一般人群中研究单元组对于理解疾病关联至关重要.
研究的目的:
- 为了测试常见的线粒体单双组是否预测缺血性心血管疾病的风险.
- 确定哈普洛组是否影响其他原因的发病率,死亡率和寿命.
- 分析这些协会在一个大,一般人口的欧洲血统.
主要方法:
- 来自哥本哈根城市心脏研究的9254人前性队列研究.
- 对缺血性心血管疾病 (25年) 和死亡率 (11年) 的随访.
- 对不同线粒体单双组的各种疾病和全因死亡率的危险比率的分析.
主要成果:
- 对缺血性心血管疾病,脑血管疾病或整体心血管疾病的危险比率没有显著差异,在哈普乐组之间与哈普乐组H相比没有明显差异.
- 对于传染病,呼吸道,瘤,消化系统,肌肉骨和神经精神疾病的发病率,也发现了类似的无意义关联.
- 所有原因死亡的危险比率在任何单双组和单双组H之间没有显著差异.
结论:
- 该研究没有发现任何证据支持常见线粒体单双组与缺血性心血管疾病风险之间的关联.
- 线粒体单双组似乎没有影响其他原因的发病率或该人口的总死亡率.
- 这些发现表明,常见的线粒体单元组可能不是欧洲人群中疾病风险或寿命的显著预测因素.
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