无症状的外周动脉疾病与间歇性音相比,与更不利的下肢特征有关
Mary M McDermott1, Jack M Guralnik, Luigi Ferrucci
1Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA. mdm608@northwestern.edu
Circulation
|May 7, 2008
概括
总是无症状的外周动脉疾病 (PAD) 患者的功能表现和小腿肌肉健康状况比间歇性关节障碍或非PAD患者差. 这凸显了无症状患者中隐藏的PAD负担.
科学领域:
- 血管医学 血管医学
- 运动生理学 运动生理学
- 肌肉骨成像系统的成像
背景情况:
- 周围动脉疾病 (PAD) 经常伴有腿部症状,如间歇性.
- 然而,PAD患者的一小部分仍然无症状,他们的功能状态和生理特征不太了解.
研究的目的:
- 评估和比较无症状PAD患者的功能性表现,小腿肌肉特征和生活质量,与间歇性关节障碍患者和健康对照患者相比.
- 为了确定无症状PAD患者的潜在生理差异.
主要方法:
- 横截面研究比较PAD参与者 (脚腕指数<0.90) 与非PAD对照 (脚腕指数0.90-1.30).
- PAD参与者被分为间歇性关节障碍和总是无症状的组.
- 使用计算机断层扫描分析了小牛肌肉组成;通过6分钟步行测试和步行速度测量评估了功能性表现;使用简短形式36问卷评估了生活质量.
- 对包括年龄,性别,种族和并发症在内的混因素进行了调整.
主要成果:
- 总是无症状的PAD患者表现出较小的小腿肌肉面积和较高的肌肉脂肪百分比,与间歇性音患者相比.
- 无症状的PAD患者表现出较差的6分钟步行表现和较慢的步行速度,而不是间歇性停滞患者和久坐,年龄相匹配的非PAD队列.
- 没有症状的PAD患者的生活质量,特别是身体功能得分,与有间歇性关节障碍患者相比,无症状PAD患者的生活质量较差.
结论:
- 没有经历腿部症状的外周动脉疾病患者的功能能力和小腿肌肉健康状况明显较差.
- 这些发现表明无症状PAD的身体功能和肌肉完整性未被识别的下降.
- 这强调了查和干预的重要性,即使没有典型的PAD症状.
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