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吸烟和戒烟与妇女死亡率的关系
Stacey A Kenfield1, Meir J Stampfer, Bernard A Rosner
1Department of Epidemiology, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. skenfiel@hsph.harvard.edu
JAMA
|May 8, 2008
概括
戒烟显著降低了女性的死亡风险,血管风险迅速减少,肺部疾病风险在20年内减少. 早期开始吸烟会增加患有呼吸道疾病和吸烟相关癌症的死亡率.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 在瘤学瘤学.
背景情况:
- 吸烟是众所周知的许多死亡原因的风险因素.
- 戒烟对降低死亡风险的确切影响需要进一步阐明.
- 证据将吸烟与卵巢和结直肠癌联系在一起仍然没有确定性.
研究的目的:
- 调查吸烟和戒烟与女性整体和因特定死亡率之间的联系.
- 量化与吸烟相关的死亡风险和戒烟的好处.
主要方法:
- 一项前性观察性研究,涉及来自护士健康研究的104,519名女性参与者.
- 从1980年到2004年收集的后续数据.
- 危险比率 (HRs) 为总死亡率和特定原因计算,包括血管,呼吸道,肺癌,其他癌症和其他原因.
主要成果:
- 与从未吸烟者相比,目前吸烟者对总死亡率 (HR,2.81) 和因特定原因死亡率的风险明显更高.
- 在目前的吸烟者中,与吸烟相关的癌症的风险显著增加 (HR,7.25).
- 戒烟后的死亡风险随着时间的推移而降低,在所有原因的死亡率方面,在20年内接近从未吸烟者的水平.
结论:
- 戒烟迅速缓解血管死亡风险,并在20年内降低肺部疾病死亡风险.
- 延迟开始吸烟与呼吸系统疾病,肺癌和其他与吸烟相关的癌症风险降低有关.
- 吸烟与结直肠癌死亡率增加的风险有关,但与卵巢癌死亡率无关.
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