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Updated: May 7, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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Published on: August 25, 2021

多基因事件协同促进Pten-null白血病干细胞的形成

Wei Guo1, Joseph L Lasky, Chun-Ju Chang

  • 1Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California 90095, USA.

Nature
|May 9, 2008
PubMed
概括

在小鼠干细胞中的Pten删除会通过激活β-catenin和c-myc. 这项研究确定了白血病干细胞转化中的关键分子事件.

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