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Updated: Apr 13, 2026

A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl
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A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl

Published on: November 28, 2014

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大酶A分裂了线粒体复合体I蛋白,以启动独立于酶的细胞死亡

Denis Martinvalet1, Derek M Dykxhoorn, Roger Ferrini

  • 1Immune Disease Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

Cell
|May 20, 2008
PubMed
概括

杀伤性淋巴细胞蛋白酶大酶A (GzmA) 通过准线粒体复合体I诱导细胞死亡.GzmA分裂NDUFS3,破坏功能并产生ROS,对细胞死亡至关重要.

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