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在动脉支架过程中进行血栓保护和血小板抑制

Christopher J Cooper¹, Steven T Haller, William Colyer

¹Cardiovascular Division, University of Toledo, 3000 Arlington Ave, MS 1036, Toledo, OH 43614, USA. Christopher.cooper@utoledo.edu

|May 21, 2008

概括

脏动脉支架可以损害脏功能. 与栓塞性保护装置和abciximab (一种糖蛋白IIb/IIIa抑制剂) 的联合治疗可以保持功能,而不是单独治疗.

科学领域:

心血管干预心血管干预
腎臟病學 (nephrology) 是一種醫學專業.
干预心脏病学干预心脏病学

背景情况:

在动脉支架时,保持功能至关重要.
动脉栓塞是术后功能障碍的已知原因之一.
血栓保护装置和糖蛋白IIb/IIIa抑制剂在维护功能方面的疗效尚不清楚.

研究的目的:

评估栓保护装置和糖蛋白IIb/IIIa抑制剂在动脉支架期间的辅助使用.
为了确定这些干预措施是否改善或保持术后的功能.

主要方法:

一个2x2的因数设计随机选择了100名接受脏动脉支架的患者.
干预包括一个栓塞保护装置 (Angioguard) 和一种糖蛋白IIb/IIIa抑制剂 (abciximab).
用1个月的饮食修改病 (MDRD) 公式评估了淋巴细胞过率 (GFR) 的变化.

主要成果:

单独使用动脉支架,使用栓塞保护或单独使用abciximab导致GFR的下降.
使用Angioguard和abciximab的联合治疗预防了GFR下降,并且优于其他组.
在过器中,abciximab显著降低了富含血小板的血栓 (42%至7%).

结论:

动脉支架,有或没有栓塞保护或单独使用abciximab,与功能下降有关.
观察到一种相互作用,与组合疗法显示优异的功能保存.
Angioguard和abciximab的组合在动脉支架过程中对保持功能提供了潜在的益处.

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