代谢综合征可以有用地预测心血管疾病和糖尿病吗? 来自两个前性研究的结果数据
Naveed Sattar1, Alex McConnachie, A Gerald Shaper
1Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. nsattar@clinmed.gla.ac.uk
Lancet (London, England)
|May 27, 2008
概括
代谢综合征预测了老年人2型糖尿病风险,但与心血管疾病风险的联系很弱. 对于每个条件,建议使用单独的风险算法.
科学领域:
- 老年学是指老年学的学科.
- 代谢疾病 代谢疾病
- 心血管健康 心血管健康
背景情况:
- 代谢综合征标准对预测并发心血管疾病 (CVD) 和糖尿病风险的临床实用性尚不确定.
- 研究了代谢综合征及其组成部分与老年人群中心血管疾病和糖尿病风险之间的关联.
研究的目的:
- 确定代谢综合征及其各个组成部分在多大程度上预测了老年人发生心血管疾病和2型糖尿病的风险.
主要方法:
- 利用了在高危老年人中对普拉瓦斯塔丁的前性研究 (PROSPER) 和英国区域心脏研究 (BRHS) 的数据.
- 根据国家胆固醇教育计划第三次报告的标准定义了代谢综合征.
- 代谢综合征及其五个组成部分与60-82岁的非糖尿病参与者发生的心血管疾病和2型糖尿病有关.
主要成果:
- 代谢综合征与糖尿病风险增加有关 (PROSPER:HR 4.41;BRHS:RR 7.47),其成分,特别是葡萄糖,强烈预测了糖尿病.
- 在PROSPER (HR 1.07) 中,代谢综合征与心血管疾病风险没有显著的关联,但在BRHS (RR 1.27) 中则存在适度的关联.
- 个人成分如BMI,甘油三和葡萄糖与心血管疾病风险无关,但所有成分都预测了新发糖尿病.
结论:
- 代谢综合征及其组成部分与老年人2型糖尿病有很强的联系.
- 在这个人群中,代谢综合征与血管风险的相关性很弱或不存在.
- 目前对代谢综合征的标准对于同时预测心血管疾病和糖尿病风险是没有帮助的;建议使用单独的风险算法.
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