埃斯基塔洛普拉姆和解决问题的治疗预防中风后抑郁症:一个随机对照试验
Robert G Robinson1, Ricardo E Jorge, David J Moser
1Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. robert-robinson@uiowa.edu
JAMA
|May 29, 2008
概括
与安慰剂相比,埃斯基塔洛普拉姆显著降低了中风后抑郁症. 解决问题的治疗显示出趋势,但在预防中风后抑郁症方面没有达到统计学意义.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 临床试验 临床试验
背景情况:
- 脑卒中后抑郁症影响超过50%的中风幸存者.
- 它与较差的恢复和增加的死亡率有关.
- 预防抑郁症是中风治疗的一个关键目标.
研究的目的:
- 评估埃斯基塔洛普拉姆和解决问题的治疗,以预防中风后抑郁症.
- 为了在12个月的时间内比较它们与安慰剂的疗效.
主要方法:
- 一个多站点随机对照试验,涉及176名非抑郁性中风患者.
- 三组:埃斯基塔洛普拉姆,解决问题的治疗和安慰剂.
- 在12个月内使用DSM-IV标准评估大/小抑郁症.
主要成果:
- 与安慰剂相比,埃斯基塔洛普拉姆显著降低了抑郁症发生率 (8.5%与22.4%相比).
- 解决问题的治疗也显示了减少 (11.9%对22.4%),但不那么明显.
- 治疗意图分析证实了埃斯基塔洛普拉姆的优越性,而解决问题的治疗与安慰剂没有显著差异.
结论:
- 埃斯基塔洛普拉姆是有效的预防中风后抑郁症.
- 解决问题的疗法的有效性需要进一步的研究.
- 两组之间没有观察到不良事件的显著差异.
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