在体内以磁共振成像测定pH值,使用超极化13C标记二碳酸盐
Ferdia A Gallagher1, Mikko I Kettunen, Sam E Day
1Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
Nature
|May 30, 2008
概括
这项研究引入了一种新的方法,使用超极化碳酸盐来图像组织pH值. 这种技术成功地检测出小鼠瘤的低pH值,为临床疾病检测提供了潜力.
科学领域:
- 生物医学成像技术 生物医学成像技术
- 医学物理 医学物理
- 生物化学 生物化学
背景情况:
- 组织pH值的改变与各种疾病有关.
- 组织pH的临床成像可以帮助疾病检测和治疗监测.
- 动态核极化 (DNP) 可以提高MRI的灵敏度.
研究的目的:
- 开发和展示一种用于体内组织pH成像的新方法.
- 为了利用超极化碳酸盐进行敏感的pH测量.
- 评估pH成像临床翻译的可行性.
主要方法:
- 通过静脉注射高极化二碳酸盐 (H(13) CO(3) ((-)).
- 使用MRI测量超极化H ((13) CO ((3))) 和 (13) CO ((2) 之间的信号强度比.
- 该技术在小鼠瘤模型中的应用.
主要成果:
- 组织pH的成功体内成像得到了实现.
- 发现瘤间歇性pH值明显低于周围组织.
- 超极化H(13)CO(3)(-) 到 (13)CO(2) 信号的比率与pH相关.
结论:
- 超极化二碳酸盐MRI可实现非侵入性组织pH成像.
- 这种技术可以在癌症等病理条件下识别pH值差异.
- 该方法有望用于临床应用,用于检测与pH值变化相关的疾病,如癌症,缺血和炎症.
![Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59399.jpg&w=3840&q=50)
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