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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
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婴儿期感染和突发意外死亡:系统的回顾性病例审查
M A Weber1, N J Klein, J C Hartley
1Department of Paediatric Pathology, Great Ormond Street Hospital for Children and the Institute of Child Health, University College London, London, UK.
Lancet (London, England)
|June 3, 2008
概括
在许多情况下,婴儿突然意外死亡 (SUDI) 仍然无法解释. 然而,像金黄色葡萄球菌和大肠杆菌这样的特定细菌可能与SUDI死亡有关,即使最初没有明显的感染.
科学领域:
- 儿科病理学 儿科病理学
- 传染病流行病学 传染病流行病学
- 法医医学 法医医学
背景情况:
- 尽管进行了彻底的尸检,但大多数婴儿突然意外死亡 (SUDI) 的病因尚不清楚.
- 这项研究调查了感染在SUDI病例中的潜在作用.
研究的目的:
- 为了确定细菌感染是否是SUDI的原因.
- 识别与无法解释的婴儿死亡相关的特定病原体.
主要方法:
- 从1996年至2005年,对546名婴儿 (7-365天) 尸检的回顾性案例审查.
- SUDI病例的分类:不明原因,由细菌感染解释,或非感染性原因.
- 将微生物分离物分类为非病原体,1组或2组病原体.
主要成果:
- 在无法解释的SUDI病例 (19%) 和细菌感染病例 (24%) 中,与非传染性病因 (11%) 相比,第二组病原体的流行率明显高.
- 黄金葡萄球菌和大肠杆菌在不明原因的SUDI病例中比在非传染病例中更频繁地被发现.
- 在93%的符合条件的SUDI病例中进行了细菌学采样,产生了大量的分离物.
结论:
- 虽然许多SUDI病例的死后培养物产生了有机体,但大多数可能是偶然发现.
- 在不明原因的SUDI中,2组病原体,特别是S. aureus和E. coli的高检测率表明与该病症的潜在关联.
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