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在抗菌素路径中对光盘多基基酸循环的编排

Kathrin Fritzsche1, Keishi Ishida, Christian Hertweck

  • 1Leibniz Institute for Natural Product Research and Infection Biology, HKI, Department of Biomolecular Chemistry, Beutenbergstr. 11a, 07745 Jena, Germany.

Journal of the American Chemical Society
|June 7, 2008
PubMed
概括

电阻菌素的生物合成涉及到一个独特的五环 discoid 结构,与典型的多基类不同. 它的形成需要聚基合成酶 (PKS) 和三种特定的循环酶的协调作用,这表明一种新的酶机制.

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