对于儿童和青少年注意力缺陷/多动障碍的Hypericum perforatum (圣约翰草):一个随机对照试验
Wendy Weber1, Ann Vander Stoep, Rachelle L McCarty
1School of Naturopathic Medicine, Bastyr University, Kenmore, Washington, USA. wendyw@bastyr.edu
在一项为期8周的试验中,圣约翰草 (Hypericum perforatum) 与安慰剂相比,在儿童中没有显著改善注意力缺陷/多动障碍 (ADHD) 的症状.
科学领域:
- 儿童精神病学 儿童精神病学
- 草药研究 草药研究
- 临床试验 临床试验
背景情况:
- 注意缺陷/多动障碍 (ADHD) 影响了相当一部分年轻人,兴奋剂药物是常见的治疗方法.
- 许多家长正在探索ADHD的替代疗法,包括植物选择,如Hypericum perforatum (圣约翰草).
- 圣约翰草是一般人最常用的三大植物药物之一.
研究的目的:
- 评估Hypericum perforatum在治疗儿童多动症时的疗效和安全性.
- 为了比较圣约翰草与安慰剂在儿童多动症患者群体中的作用.
主要方法:
- 一项随机,双盲,安慰剂对照试验与54名被诊断患有多动症的儿童 (年龄在6-17岁) 进行.
- 参与者接受了300毫克的H. perforatum (标准化为0.3%的超素) 或安慰剂,每天三次,持续八周.
- 使用ADHD评分尺度-IV和临床全球印象改善尺度评估症状变化,并监测不良事件.
主要成果:
- 在H. perforatum组和安慰剂组之间,ADHD症状 (注意力不集中或过度活动) 的改善没有观察到统计学上显著的差异.
- 符合临床改善标准的参与者百分比在治疗组和安慰剂组都相似.
- 在接受H. perforatum和接受安慰剂的儿童之间,不良事件的发生率是可比的,没有发现显著差异.
结论:
- 八周的Hypericum perforatum治疗没有证明有效改善儿童的多动症 (ADHD) 症状.
- 这项研究表明,根据评估结果,圣约翰草不是治疗儿童多动症的有效治疗方法.
- 进一步的研究可能是有必要的,但目前的证据不支持在这个年龄段使用H. perforatum治疗ADHD.
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