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在psmad3和Notch之间的不平衡会在老肌肉干细胞中诱导CDK抑制剂

Morgan E Carlson1, Michael Hsu, Irina M Conboy

  • 1Department of Bioengineering, University of California, Berkeley, California 94720, USA.

Nature
|June 17, 2008
PubMed
概括

衰老的肌肉干细胞由于Notch激活的减少和转化生长因子-β (TGF-β) 的增加而失去再生能力. 恢复诺奇和TGF-β信号之间的平衡,可以恢复老年人的肌肉修复.

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