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A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
11:44

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

Published on: January 24, 2016

在多发性骨髓瘤中IRF4成

Arthur L Shaffer1, N C Tolga Emre, Laurence Lamy

  • 1Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

Nature
|June 24, 2008
PubMed
概括

干扰素调节因子4 (IRF4) 的抑制对多发性骨髓瘤细胞有毒,揭示了各亚型的共同脆弱性. 这项研究揭示了一个关键的IRF4-MYC自我调节电路,驱动骨髓瘤的进展.

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