脊心前祖细胞在发育中的心脏中为心肌细胞谱系做出贡献
Bin Zhou1, Qing Ma, Satish Rajagopal
1Harvard Stem Cell Institute and Department of Cardiology, Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
Nature
|June 24, 2008
概括
研究人员发现了新的Wt1(+) 表心细胞,在心脏发育过程中充当心肌细胞前代. 这些细胞为未来的心脏再生和修复策略提供了潜力.
科学领域:
- 心血管生物学 心血管生物学
- 发展生物学 发展生物学
- 干细胞研究 干细胞研究
背景情况:
- 成熟的心脏来自表达转录因子Nkx2-5和Isl1.1的多能原始体.
- 这些原始细胞产生心肌细胞,光滑肌肉和内皮细胞系.
研究的目的:
- 为了确定参与心脏发育的新型心脏原生前体.
- 为了研究Wt1表达细胞在上心脏中的作用.
主要方法:
- 利用小鼠模型研究正常的心脏发育.
- 在上心脏内识别和特征Wt1(+) 细胞.
主要成果:
- 一个Wt1(+) 表心前体的子集,分化为心肌细胞.
- Wt1(+) 前皮心细胞起源于 Nkx2-5(+) 和 Isl1(+) 的原始细胞.
- 在Wt1(+) 和Nkx2-5(+) /Isl1(+) 的祖先之间建立了共同的发育起源.
结论:
- 鉴定了Wt1(+) 表心细胞作为心肌细胞原始体的以前未知的来源.
- 这些发现为利用这些原始体在心脏再生和修复中提供了基础.
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