相关实验视频

Updated: Aug 19, 2026

Residue-specific Incorporation of Noncanonical Amino Acids into Model Proteins Using an Escherichia coli Cell-free Transcription-translation System
11:47

Residue-specific Incorporation of Noncanonical Amino Acids into Model Proteins Using an Escherichia coli Cell-free Transcription-translation System

Published on: August 1, 2016

通过谷氨基-tRNA合成酶对抗环识别的结构基础

M A Rould1, J J Perona, T A Steitz

  • 1Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511.

Nature
|July 18, 1991
PubMed
概括

氨基转移RNA合成酶与转移RNA (tRNA) 和ATP结合的抗环显示出独特的结构变化. 这些变化使特定的结合成为可能,使酶能够准确地选择正确的tRNA.

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One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
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