一个布伦斯特德酸催化剂,用于酶选择性质子反应反应
Cheol Hong Cheon1, Hisashi Yamamoto
1Department of Chemistry, University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA.
Journal of the American Chemical Society
|June 28, 2008
概括
开发了一种新型的性布伦斯特德酸催化剂,用于无金属的enantioselective质子化. 这种催化剂有效地以高的选择性质质量质子化乙醇,即使在低负载下也是如此.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 不对称的合成方法
背景情况:
- 希拉尔布伦斯特德酸是不对称合成中的关键催化剂.
- 开发无金属催化剂是绿色化学的一个关键目标.
- 随机选择性质子是创建奇拉分子的基本转换.
研究的目的:
- 开发一种新的,高度反应的,强大的性布伦斯特德酸催化剂.
- 为了证明第一个无金属的 Brønsted 酸催化了 silyl enol 以太的 enantioselective 质子化.
- 为了研究催化剂在低负荷下的效率.
主要方法:
- 合成一种性N-triflyl thiophosphoramide催化剂.
- 催化剂在乙醇乙的选择性质子化中的应用.
- 反应条件和催化剂负载的优化.
主要成果:
- 成功开发了一种高反应性和强大的性N-triflyl thiophosphoramide催化剂.
- 催化剂使得第一个无金属的布伦斯特德酸催化西乙醇的反选择性质子形成.
- 即使具有0.05mol%的催化剂负荷,也可以达到高的选活性.
结论:
- 奇拉尔N-triflyl thiophosphoramide是一种有效的催化剂,用于无金属的enantioselective质子.
- 这种方法提供了一个绿色和高效的途径,以奇拉化合物.
- 催化剂的低负载要求提高了其实际适用性.
相关概念视频
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