相关实验视频

Updated: Jul 3, 2026

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
08:35

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

Published on: June 24, 2021

对基因活动和通过对人类转录基因组进行深度测序的替代拼接的全球视图

Marc Sultan1, Marcel H Schulz, Hugues Richard

  • 1Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany.

Science (New York, N.Y.)
|July 5, 2008
PubMed
概括

这项研究对人类转录组进行了测序,揭示了新的基因拼接接口和替代拼接事件. RNA-Sequencing (RNA-Seq) 发现的基因多于微阵列,增强了我们对人类转录组的理解.

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Alternative RNA Splicing02:18

Alternative RNA Splicing

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Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...
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