在高性心肌病症中对仰卧运动的异常血管反应
P J Counihan1, M P Frenneaux, D J Webb
1Department of Cardiological Sciences, St. George's Hospital Medical School, London, UK.
Circulation
|August 1, 1991
概括
运动期间异常的外周血管反应与高压心肌病 (HCM) 中的运动低血压有关. 这些血液动力学不稳定性,特别是在患有高血压病史的年轻患者中,可能会导致心脏突然死亡.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 血管生物学 血管生物学
背景情况:
- 运动低血压在高性损心肌病 (HCM) 中观察到.
- 这种低血压并不是由于心脏输出受损,而是由于高工作负载期间系统血管阻力不适当下降.
研究的目的:
- 为了研究HCM患者在运动期间的外周血管反应.
- 确定异常血管反应与HCM运动低血压之间的关系.
主要方法:
- 103名HCM患者进行了仰卧式自行车运动,并测量了前臂的血流量.
- 前臂血流减少至少12%被认为是正常的.
- 患者还接受了跑步机运动测试,以评估勃起运动期间的血压反应.
主要成果:
- 观察了两种前臂血流模式:64名患者有适当的减少,而39名患者没有减少或增加.
- 患有前臂血流反应异常的患者年轻,家族病史和突然死亡的发生率更高.
- 在39名前臂血流反应异常的患者中,31名在勃起测试期间表现出运动低血压.
结论:
- 异常的外周血管反应与HCM中的运动低血压相关,表明血液动力学不稳定.
- 高风险患者中异常血管反应的存在表明,血液动力学机制在HCM中突然心脏死亡中起着作用.
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