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老年人中的Fetuin-A和发生糖尿病
Joachim H Ix1, Christina L Wassel, Alka M Kanaya
1Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, and San Diego Veterans Affairs Healthcare System, 3350 La Jolla Village Dr, Mail Code 111-H, San Diego, CA 92161, USA. joeix@ucsd.edu
JAMA
|July 10, 2008
概括
较高的血清Fetuin-A水平预测了老年人患2型糖尿病的风险增加. 这一发现独立于其他胰岛素抵抗标志物,表明fetuin-A是糖尿病风险的潜在生物标志物.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 老年学是指老年学的学科.
背景情况:
- 费图因-A是一种已知的肝分泌蛋白质,可以在体外抑制胰岛素的作用.
- 以前的横截面研究将较高的fetuin-A水平与人类的胰岛素抵抗有关.
- 费图因-A与发生的2型糖尿病之间的纵向关联仍然未知.
研究的目的:
- 调查血清Fetuin-A水平与老年人2型糖尿病发生率之间的关联.
- 确定fetuin-A是否是该人群中发生糖尿病的独立预测因素.
主要方法:
- 在3075名70-79岁的功能良好个体中进行了病例和队列研究.
- 测量了406名没有患有糖尿病的参与者和所有在6年内患有发病糖尿病的参与者的基线血清中的Fetuin-A水平.
- 糖尿病发病率是主要的结果指标.
主要成果:
- 在随访期间,135名参与者患上糖尿病.
- 与最低三位数 (<或=0.76 g/L) 相比,fetuin-A最高三位数 (>0.97 g/L) 的个体显示出发生糖尿病的风险明显增加 (aHR,2.41;95% CI,1.28-4.53).
- 这种关联在调整多个混因素 (包括代谢和炎症标志物) 后仍然显著,并且仅因内脏脂肪性而适度减弱.
结论:
- 血清Fetuin-A水平在功能良好的老年人中与患2型糖尿病的风险增加长度相关.
- 费图因-A作为发生糖尿病的独立预测剂,超出了胰岛素耐药性的其他已确定的标志物.
- 这些发现凸显了fetuin-A作为老年人群糖尿病风险生物标志物的潜在作用.
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