进化和不断扩大的进化合成:形态进化的遗传理论
1Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin-Madison, Madison, WI 53706, USA. sbcarrol@wisc.edu
Cell
|July 11, 2008
概括
形态多样性通过改变基因表达而进化,主要是通过 cis 调节序列的变化. 这种遗传理论解释了进化如何通过修改保存的蛋白质及其调节网络来塑造生物形式.
科学领域:
- 进化发育生物学 进化发育生物学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 了解形态进化的遗传基础是一个长期存在的生物学挑战.
- 形态多样性源于基因序列及其功能的变化.
研究的目的:
- 概述八个指导形态进化的遗传理论的原则.
- 审查最近关于物种分歧的研究,以告知这一理论.
主要方法:
- 从分子和进化发育生物学得出的原理.
- 对物种分歧的经验研究的审查.
主要成果:
- 提出了形态进化的遗传理论.
- 形式通过改变保存的蛋白质的表达而进化.
- 发育基因的cis调节序列中的突变驱动了这些变化.
结论:
- 形式的进化在很大程度上是由基因表达的变化驱动的.
- 关键发育基因中的Cis调节突变是形态进化的核心.
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