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Updated: Jul 3, 2026

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration
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骨肌干细胞的高效,功能性植入于肌衰竭肌肉中的干细胞

Massimiliano Cerletti1, Sara Jurga, Carol A Witczak

  • 1Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02115, USA.

Cell
|July 11, 2008
PubMed
概括

研究人员确定并分离了作为强大的肌肉干细胞的特定骨肌肉前体 (SMP). 这些SMP有效地修复肌肉组织,并恢复肌肉衰竭模型中的功能.

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...