杏仁体间隔神经元是表达恐惧的必要条件
Ekaterina Likhtik1, Daniela Popa, John Apergis-Schoute
1Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA.
Nature
|July 11, 2008
概括
间歇性 (ITC) 杏仁体神经元对于减少有条件的恐惧至关重要. 伤害这些神经元损害了恐惧的灭绝,这表明它们是治疗焦虑症的关键目标.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 焦虑症 焦虑症 研究 研究
背景情况:
- 恐惧学习和灭绝对于理解焦虑障碍至关重要.
- 杏仁体在恐惧反应中发挥着中心作用,间隔神经元 (ITC) 可能会调解灭绝.
- 通过ITC神经元影响恐惧灭绝的确切机制尚不清楚.
研究的目的:
- 调查ITC杏仁体神经元在调解恐惧灭绝中的作用.
- 测试ITC神经元通过前抑制来减少条件恐惧的假设.
- 探索针对ITC神经元治疗焦虑障碍的治疗潜力.
主要方法:
- 选择性损伤ITC神经元使用与萨波林结合的微阿片类受体 (microOR) 激动剂.
- 电子显微镜用于评估杏仁体子区域的微OR定位.
- 行为测试以测量ITC神经元损伤后恐惧灭绝的表达.
主要成果:
- 微型阿片类受体被发现高度集中在ITC神经元上,通常是突触后.
- 损伤ITC神经元显著减少了它们的数量 (34%),但没有影响周围的细胞核.
- ITC神经元病变导致恐惧灭绝表达的明显缺陷,与幸存的ITC神经元数量相关.
结论:
- ITC杏仁体神经元是恐惧灭绝的重要媒介.
- 准微OR表达ITC神经元为治疗焦虑障碍提供了一种新的策略.
- 这些发现突出了ITC细胞独特的受体表达及其治疗含义.
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