在低出生体重的儿童中,有动脉管狭窄的证据
Paul Mitchell1, Gerald Liew, Elena Rochtchina
1Centre for Vision Research, Department of Ophthalmology, University of Sydney, Westmead Hospital, Hawkesbury Rd, Westmead, New South Wales, Australia. paul_mitchell@wmi.usyd.edu.au
Circulation
|July 16, 2008
概括
胎内生长不良,由较低的出生体重表明,与儿童的视网膜动脉狭窄有关. 这一发现表明,早期生长会影响血管发育,可能会影响未来的心血管健康.
科学领域:
- 儿科心血管健康 儿童心血管健康
- 健康和疾病的发育起源 (DOHaD)
背景情况:
- 心血管疾病的风险可能起源于胎儿发育期间.
- 胎内生长对儿童微血管结构的影响尚不清楚.
研究的目的:
- 调查子宫内生长标志物与儿童视网膜微血管口径之间的关联.
- 测试假设,子宫内生长不良会导致动脉小动脉变窄,这可能解释了与高血压的联系.
主要方法:
- 在澳大利亚悉尼对1369名6岁儿童进行的一项基于人口的研究.
- 视网膜动脉和静脉口径测量使用计算机辅助方法在数字化视网膜照片.
- 从父母记录中获得的出生体重,长度和头周长.
主要成果:
- 较低的出生体重,较短的出生长度和较小的头周长显著与较窄的视网膜动脉口径有关.
- 每公斤的出生体重下降与动脉动脉口径的2.3毫米下降相关,调整多个因素.
- 对于出生长度和头部周长与动脉状口径也发现了类似的关联.
结论:
- 在子宫内生长较差的儿童表现出较窄的视网膜动脉.
- 这些发现支持了不良子宫内生长会对微血管结构发育产生负面影响的假设.
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