从具有反应性终端组的星形聚合物制成的有机纳米颗粒的设计和使用
Lieven M Van Renterghem1, Mieke Lammens, Bart Dervaux
1Department of Organic Chemistry, Polymer Chemistry Research Group, Ghent University, Krijgslaan 281 S4-bis, B-9000 Ghent, Belgium.
Journal of the American Chemical Society
|July 17, 2008
概括
星形聚合物是使用原子转移激素聚合 (ATRP) 合成的,并功能化以创建新的有机纳米粒子. 这些纳米粒子有效地改变了线性聚合物的粘弹性特性.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 原子转移基聚合 (ATRP) 是一种受控聚合技术.
- 与线性聚合物相比,星形聚合物具有独特的特性.
- 有机纳米粒子可以用来修改材料的特性.
研究的目的:
- 使用ATRP合成星形的聚乙烯酸 (PiBA).
- 为了使星聚合物功能化,以创建反应性末端组.
- 准备和描述新的PiBA纳米粒子.
- 研究这些纳米粒子作为线性聚合物的添加剂的使用.
主要方法:
- 通过ATRP使用多功能启动器合成星形PiBA.
- 优化ATRP条件以尽量减少合并最大限度地提高功能.
- 末组通过核替代的功能化.
- 通过分子内聚合制备PiBA纳米颗粒的制备.
- 使用MALDI-TOF,NMR光谱和SEC进行了表征.
- 聚合物混合物的风湿学分析.
主要成果:
- 控制合成有4,6和12个臂和不同分子重量的星形PiBA.
- 高端组功能 (>90%) 在功能化后实现.
- 在多克克尺度上成功制备PiBA纳米粒子.
- 通过加入1-20重量%的纳米颗粒,证明了调整聚-n-丁烯酸的粘弹性特性的能力.
结论:
- 星形PiBA可以被可控地合成和功能化.
- 从这些恒星聚合物中可以制备新的有机纳米粒子.
- 这些纳米粒子作为有效的添加剂,用于修改线性聚合物的粘弹性行为.
相关概念视频
Anionic Chain-Growth Polymerization: Overview
The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Ziegler–Natta Chain-Growth Polymerization: Overview
Ziegler–Natta polymerization is another form of addition or chain‐growth polymerization used for synthesizing linear polymers over branched polymers. The catalyst used for polymerization is the Ziegler–Natta catalyst, named after Karl Ziegler and Giulio Natta, who developed it in 1953. This catalyst is an organometallic complex of titanium tetrachloride and triethyl aluminum, with the active form of the catalyst being an alkyl titanium compound. Using the Ziegler–Natta catalyst, high molecular...
Step-Growth Polymerization: Overview
Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...
Many natural and synthetic polymers are produced by...


