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布拉洛克-陶西格-托马斯合作:医学进步的一个模型

Anne M Murphy1, Duke E Cameron

  • 1The Helen B. Taussig Division of Pediatric Cardiology, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. amurphy2@jhmi.edu

JAMA
|July 18, 2008
PubMed
概括

No abstract available in PubMed .

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...