内脑状态调节表膜潜在同步在行为小鼠的桶皮质
James F A Poulet1, Carl C H Petersen
1Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
Nature
|July 18, 2008
概括
在安静的清醒状态下,大脑中的附近神经元表现出高度相关的膜潜力 (V(m)). 然而,积极的鞭打会改变大脑状态,减少V (m) 相关性并改变神经元处理模式.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 内脑状态显著影响感官感知,感官运动协调和学习.
- 通过脑电图 (EEG) 和局部场电位 (LFP) 观察到的皮层同步模式,反映了哺乳动物的不同大脑状态.
- 在行为动物中,大脑状态和细胞内膜潜力 (V(m)) 动态之间的关系在很大程度上仍未被探索.
研究的目的:
- 为了研究皮层同步,大脑状态的标志,是如何反映在内细胞膜潜力 (V(m)) 神经元在行为小鼠的动态.
- 为了确定是否以及如何内部大脑状态的变化在行为过程中动态调节神经元V (m) 相关性.
主要方法:
- 利用表现性小鼠主要体感管皮层中2/3层神经元的体内全细胞双重记录.
- 在安静的清醒状态和积极的鞭打行为期间记录了细胞内膜潜力 (V(m)) 和动作潜能活动.
主要成果:
- 在安静的清醒状态下,在附近的神经元之间显示了V (m) 的高相关性.
- 表明主动,一种内部生成的状态变化,显著降低了V (m) 相关性,导致LFP和EEG脱同步.
- 观察到稀疏的动作潜能活动,由特定的激发性输入驱动,与平静时期相比,在活跃的动期间,信号与噪声比率更高.
结论:
- 内脑状态在行为过程中动态调节皮质膜潜在同步.
- 这种V (m) 同步的动态调节定义了不同的皮质处理模式,影响感官感知和感官运动协调.
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