G1环林的积极反确保了细胞循环的连贯进入
Jan M Skotheim1, Stefano Di Talia, Eric D Siggia
1Center for Studies in Physics and Biology, The Rockefeller University, New York 10065, USA. skotheim@stanford.edu
Nature
|July 18, 2008
概括
发芽酵母酵母的发芽是什么意思
科学领域:
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
- 系统生物学 系统生物学
背景情况:
- 在Saccharomyces cerevisiae中的开始检查点整合了细胞循环进入的信号.
- 现有的模型提出一个线性布启动启动.
研究的目的:
- 调查芽酵母中Start检查点的监管网络.
- 阐明反机制在细胞循环调节中的作用.
主要方法:
- 对基因删除突变 (CLN1和CLN2) 的分析.
- 研究G1/S regulon. 的转录调节.
- 评估芽效率和细胞周期进展.
主要成果:
- 由于系统级反,Start 作为一个开关.
- 转录G1环林 (Cln1和Cln2) 的正反驱动了快速的G1/S regulon表达.
- 核Cln2调节基因表达,而细胞质Cln2促进芽.
结论:
- 积极的反放大了Cln1和Cln2的表达,确保了强大的芽和连贯的G1/S regulon激活.
- 哺乳动物细胞中类似的调节架构表明保存机制或融合进化.
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