Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Meningococcal B Vaccine to Prevent <i>Neisseria gonorrhoeae</i> Infection.

The New England journal of medicine·2026
Same author

HIV cascade, key indicators, and other epidemiological metrics in Australia (2004-2023): a retrospective analysis.

The Lancet regional health. Western Pacific·2026
Same author

Barriers and Facilitators to Oral HIV Pre-exposure Prophylaxis Use in Australia: A Scoping Review Comparing Findings to Canada, New Zealand, and the United Kingdom.

AIDS and behavior·2026
Same author

Mpox disease epidemiology, vaccine uptake and vaccination coverage in Australia 2022-2024: a descriptive study.

EClinicalMedicine·2026
Same author

Barriers and Facilitators Related to Providing Long-Acting Injectable HIV Preexposure Prophylaxis in Australian Settings: A Qualitative Study of Clinical and Policy Stakeholders.

The Journal of the Association of Nurses in AIDS Care : JANAC·2026
Same author

Efficacy of the meningococcal vaccine against Neisseria gonorrhoeae: a randomised clinical trial (MenGO).

NPJ vaccines·2026

相关实验视频

Updated: Jul 3, 2026

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

艾滋病毒病毒载量和传染性之间的关系:基于模型的分析分析.

David P Wilson1, Matthew G Law, Andrew E Grulich

  • 1National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, NSW, Australia. Dwilson@nchecr.unsw.edu.au

Lancet (London, England)
|July 29, 2008
PubMed
概括

有效的抗逆转录病毒疗法显著减少但不能消除艾滋病毒传播风险. 基于非传染性声称的避孕套使用率下降可能会增加艾滋病毒发病率,特别是在男性同性恋伴侣中.

科学领域:

  • 流行病学 流行病学
  • 数学建模的数学建模
  • 公共卫生 公共卫生

背景情况:

  • 瑞士的一项共识声明表明,接受有效抗逆转录病毒疗法 (ART) 且艾滋病毒RNA无法检测的人是非传染性的.
  • 本分析检查了这一主张对艾滋病毒传播的人口层面影响.

研究的目的:

  • 估计有效治疗的个体 (HIV RNA <10副本/毫升) 传播艾滋病毒的累积风险.
  • 评估艾滋病毒不一致的夫妇在每一行为和长期性传播的风险.
  • 分析如果由于感知不传染性而导致避孕套使用减少,对艾滋病毒发病率的潜在影响.

主要方法:

  • 利用一个简单的数学模型来模拟艾滋病毒的传播.
  • 在异性恋和同性恋伴侣关系中估计的年度和累积传播概率.
  • 在一万个血清异性伙伴关系的人群中,模拟了10年的传播.

主要成果:

  • 每对夫妇的年传染风险:0.0022 (F-M),0.0043 (M-F),0.043 (M-M).每对夫妇的年传染风险:0.0022 (F-M),0.0043 (M-F),0.043 (M-M).每对夫妇的年传染风险:0.0022 (F-M),0.0043 (M-F),0.043 (M-M).每对夫妇的年传染风险:0.0022 (F-M),0.0043 (M-F),0.043 (M-M).
  • 在10年内,预计有1万个伙伴关系的血清转化:215个 (F-to-M),425个 (M-to-F),3524个 (M-to-M).

更多相关视频

Pairwise Growth Competition Assay for Determining the Replication Fitness of Human Immunodeficiency Viruses
11:19

Pairwise Growth Competition Assay for Determining the Replication Fitness of Human Immunodeficiency Viruses

Published on: May 4, 2015

Humanized NOD/SCID/IL2r&#947;null (hu-NSG) Mouse Model for HIV Replication and Latency Studies
07:10

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

相关实验视频

Last Updated: Jul 3, 2026

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

Pairwise Growth Competition Assay for Determining the Replication Fitness of Human Immunodeficiency Viruses
11:19

Pairwise Growth Competition Assay for Determining the Replication Fitness of Human Immunodeficiency Viruses

Published on: May 4, 2015

Humanized NOD/SCID/IL2r&#947;null (hu-NSG) Mouse Model for HIV Replication and Latency Studies
07:10

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

  • 与目前的避孕套使用率相比,艾滋病毒发病率可能增加四倍.

    • 结论:

    • 在有效治疗的异性恋伴侣关系中,艾滋病毒传播风险很低,但不等于零.
    • 在重复暴露的男性同性恋伴侣关系中,传播风险仍然很高.
    • 广泛接受非传染性声明和减少避孕套的使用可能会导致艾滋病毒发病率的显著增加.