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Updated: Jul 3, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates

Published on: February 27, 2016

依赖NAD+的脱乙酶SIRT1调节了CLOCK介导的染色质重塑和昼夜控制

Yasukazu Nakahata1, Milota Kaluzova, Benedetto Grimaldi

  • 1Department of Pharmacology, University of California, Irvine, CA 92697, USA.

Cell
|July 30, 2008
PubMed
概括

昼夜时钟蛋白CLOCK乙化基因组 H3 和 BMAL1. 依赖NAD ((+) 的脱乙酶SIRT1通过脱乙这些蛋白质来调节昼夜节律,作为一个关键的代谢传感器.

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