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Updated: Jul 3, 2026

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
07:44

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes

Published on: July 6, 2016

通过UVB光在酸性pH值的寡氧核酸中高产量产生的一种跨链类型的cis-anti-cyclobutane胺二元体的结构确定

Dian G T Su1, Jeffrey L-F Kao, Michael L Gross

  • 1Department of Chemistry, Washington University, St. Louis, Missouri 63130, USA.

Journal of the American Chemical Society
|August 6, 2008
PubMed
概括

研究人员在酸性条件下在特定的DNA序列中发现了一种新型的DNA光产物,该光产物是在胺基T2和T7之间形成的. 这种跨链环丁胺二聚体形成表明可能存在新的DNA折叠模式.

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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism11:37

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相关概念视频

Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...