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相关概念视频

An Application for Pairing with Wearable Devices to Monitor Personal Health Status06:58

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The present protocol introduces a non-commercial self-developed application for collecting real-time on-site data, including psychological scales, GPS location, heart rate, and blood-oxygen saturation level, as well as the application's operating procedures. An empirical study conducted in Taiwan in 2020 was used as an application...
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Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack07:31

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We demonstrate how to deploy a real-time psychosis risk calculation and alerting system based on CogStack, an information retrieval and extraction platform for electronic health...
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Oral Health Assessment by Lay Personnel for Older Adults08:47

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The goal of this protocol is to enable non-dental professionals to assess oral health status for research or health-screening purposes. Aspects assessed include lips, tongue, soft and hard tissues, natural and artificial teeth, oral cleanliness, plaque, swallowing, and impact of oral health on quality of...
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Necropsy-based Wild Fish Health Assessment07:57

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The health of wild fishes can be used as an indicator of aquatic ecosystem health. Necropsy-based fish health assessments provide documentation of visible lesions or abnormalities, data used to calculate condition indices as well as the opportunity to collect tissues for microscopic evaluation, gene expression and other more in-depth...
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Biomarkers are directly-measured biological indicators of disease or health. In population and social sciences, biomarkers need to be easy to obtain, transport, and analyze. Dried Blood Spot (DBS) collection meets this need, can be collected in the field with high response rates and analyzed for a variety of...
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We demonstrate the utility of nest building behavior in laboratory mice as an indicator of welfare. Nest scoring is a sensitive technique that is altered by temperature, illness, and aggression. The time to integrate into nest test (TINT) is a simple cage-side assessment that can detect postoperative...
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Updated: Feb 5, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
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疾病特异性诱导的多能干细胞干细胞.

In-Hyun Park1, Natasha Arora, Hongguang Huo

  • 1Department of Medicine, Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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研究人员从患有各种遗传疾病的患者中产生诱导多能干细胞 (iPS). 这些患者特异性干细胞使得人体疾病的体外建模能够用于研究和药物发现.

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科学领域:

  • 干细胞生物学 干细胞生物学
  • 遗传学 遗传学 是一个
  • 医学研究 医学研究

背景情况:

  • 来自患者的细胞的组织培养对于医学研究至关重要.
  • 目前的资源仅限于瘤细胞系或转化组织.
  • 需要针对遗传疾病的多样化,针对患者的细胞模型.

研究的目的:

  • 从一系列遗传疾病患者中产生诱导多能干细胞 (iPS).
  • 建立一种疾病特异性干细胞资源,用于体外疾病建模.
  • 促进对遗传性疾病的调查和药物开发.

主要方法:

  • 从患者体细胞生成诱导多能干细胞 (iPS).
  • 使用重编程技术来实现多能性.
  • 来自各种遗传疾病背景的iPS细胞的特征.

主要成果:

  • 从患有孟德尔和复杂遗传疾病的患者中成功生成iPS细胞.
  • 包括严重的综合免疫缺陷,肌肉发育不良,帕金森病和糖尿病等疾病.
  • 建立了患者衍生,疾病特异性的多能干细胞的集合.

结论:

  • 来自患者的诱导多能干细胞为研究人体疾病提供了强大的工具.
  • 这些疾病特异性干细胞能够重复正常和病态组织的形成.
  • 这种资源对于推进疾病研究和治疗开发是非常宝贵的.