发烧发作儿童死亡:基于人口的队列研究
Mogens Vestergaard1, Marianne Giørtz Pedersen, John R Ostergaard
1Department of General Practice, Institute of Public Health, Aarhus University, Aarhus, Denmark. mogens.vestergaard@alm.au.dk
Lancet (London, England)
|August 12, 2008
概括
患有发烧的儿童的长期死亡率没有增加. 然而,复杂的发烧发作与两年内死亡率略有增加有关,通常与神经问题有关.
科学领域:
- 儿科神经学 儿科神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 关于发烧性发作儿童死亡率的数据有限.
- 需要进行大规模的人口研究来准确评估风险.
研究的目的:
- 在一个大规模的丹麦儿科队列中调查发烧性后的长期死亡率.
- 确定与死亡率增加相关的特定风险因素和发作类型.
主要方法:
- 利用全国性的丹麦登记册来识别1977-2004年间出生的167万名儿童.
- 用于死亡率估计的生存分析和用于详细分析的嵌套病例控制研究.
- 追踪儿童长达28年,将健康和死亡记录联系起来.
主要成果:
- 在发烧之后,整体的长期死亡率没有增加.
- 在复杂发烧发作后的两年内,观察到较小的过度死亡率 (调整后的死亡率比率为1.99).
- 预先存在的神经异常和部分解释了复杂病例中死亡率的增加.
结论:
- 发烧性发作不会增加儿童的长期死亡风险.
- 复杂发烧发作需要更密切的监测,因为死亡风险暂时增加.
- 为父母提供了关于发烧发作后死亡的稀有性的保证.
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