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PTEN的二维基提尼化和局部化由HAUSP-PML网络进行调节

Min Sup Song1, Leonardo Salmena, Arkaitz Carracedo

  • 1Cancer Genetics Program, Beth Israel Deaconess Cancer Center and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

Nature
|August 22, 2008
PubMed
概括

核PTEN (在染色体10中删除的酸酶和张素同类物) 的排除驱动癌症. 一个新的PML-DAXX-HAUSP网络控制PTEN二维基化和核入口,提供有关癌症进展的见解.

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