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Updated: Jul 2, 2026

A Yeast 2-Hybrid Screen in Batch to Compare Protein Interactions
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A Yeast 2-Hybrid Screen in Batch to Compare Protein Interactions

Published on: June 6, 2018

酵母互动组网络的高质量二元蛋白相互作用地图

Haiyuan Yu1, Pascal Braun, Muhammed A Yildirim

  • 1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Science (New York, N.Y.)
|August 23, 2008
PubMed
概括

这项研究揭示了使用酵母两杂交 (Y2H) 查的酵母中高质量的二元蛋白相互作用. 新的交互原子地图突出显示了必不可少的蛋白质之间的短暂信号和连接,将连接性与遗传变性相关联.

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
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