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Updated: Jul 2, 2026

A Live-cell Image-Based Machine Learning Strategy to Monitor Pluripotent Stem Cell Differentiation
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A Live-cell Image-Based Machine Learning Strategy to Monitor Pluripotent Stem Cell Differentiation

Published on: October 4, 2024

监管网络定义了人类干细胞系的表型类别

Franz-Josef Müller1, Louise C Laurent, Dennis Kostka

  • 1Center for Regenerative Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. fj.mueller@zip-kiel.de

Nature
|August 30, 2008
PubMed
概括

研究人员开发了一种干细胞矩阵,使用基因表达特征来分类人类干细胞. 这种方法将多能干细胞组合在一起,并确定多能性特征的共享蛋白质网络 (PluriNet).

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Regulation of Hematopoietic Stem Cells

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Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
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