空气颗粒污染是冠状动脉疾病患者ST段抑郁症的风险因素
Kai Jen Chuang1, Brent A Coull, Antonella Zanobetti
1Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA.
Circulation
|September 10, 2008
概括
暴露于细颗粒物 (PM2.5) 和黑碳空气污染物与心脏病患者的ST段抑郁有关. 这种风险在最近心肌损伤的个体中增加,特别是在事件发生后的第一个月内.
科学领域:
- 环境健康 环境健康
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 暴露于颗粒物 (PM) 是心血管疾病的已知风险因素.
- 颗粒物诱导的缺血是一种可疑的机制,将污染与心脏不良事件联系起来.
研究的目的:
- 调查环境空气污染与心脏病患者的ST段变化之间的关联.
- 识别特定的污染物和患有更高风险的患者子组.
主要方法:
- 一项重复测量研究,涉及48名心脏病患者,监测时间长达1年.
- 24小时的霍尔特心电图监测测量了ST段水平,与环境PM2.5和黑碳水平相关联.
- 分析包括患有心肌梗塞,急性冠状动脉综合征或稳定冠状动脉疾病的患者.
主要成果:
- 较高的细颗粒物 (PM2.5) 和黑碳水平预测了ST段的低压.
- 在增加的黑碳暴露和ST段抑郁之间发现了显著的关联.
- 最近心肌梗塞或糖尿病患者,以及住院后的第一个月内,影响更为明显.
结论:
- 心脏病患者的ST段抑郁与暴露于PM2.5和黑碳有关.
- 与污染相关的ST段抑郁症的风险在最近心肌损伤的患者中增加,特别是在心脏事件发生后的第一个月内.
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